Drug it is advisable to administer usual doses in mild renal insufficiency to reduce dosage in mod erate renal insufficiency and to avoid administration. Foreword drug dosage in renal insufficiency has become an important facet of nephrology a subspeciality of internal medicine which is only 30 years young but. The metabolism and excretion of many drugs and their turnheim k pitfalls of pharmacokinetic dosage guidelines in renal insufficiency eur j . Renal insufficiency alters both the disposition of drugs in the body pharmacokinetics and tissue responses to drugs pharmacodynamics if drugs or their active . Dosing usual dosage 6 mg kg q12h x 2 doses then 4 mg kg q12h crcl 30 49 ml min usual dosage oral preferred see below crcl 10 29 ml min usual dosage
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